May 1, 2002 · Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

6 days ago · The SOCS box is an approximately 40 amino acid region of homology originally identified in members of the supressors of cytokine signaling (SOCS) family of proteins. The SOCS box is always located at the C terminus and appears to …

Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

The SOCS (Suppressors of Cytokine Signalling) family of proteins inhibit the cytokine induced signalling cascade, in part by promoting the ubiquitination of signalling intermediates that are then targeted for proteasomal degradation.

The SOCS box is found in a diverse array of intracellular signalling molecules, many of which contain different protein interaction domains such as SPRY and WD40 domains, leucine and ankyrin repeats or other functional domains such as GTPases.

Oct 1, 2008 · The suppressors of cytokine signalling (SOCS) box is a structural domain found at the C-terminus of over 70 human proteins. It is usually coupled to a protein interaction module such as an SH2 domain in case of SOCS proteins, a family of modulators of cytokine signaling.

SOCS-box proteins recruit substrates to the ECS complex and are linked to Cullin-Rbx via Elongin B/C. VHL has been implicated as a SOCS-box protein, but lacks a C-terminal sequence (downstream of the BC box) of the SOCS box.

SOCS boxes, including MUF-1, the von Hippel–Lindau (VHL) tumor suppressor protein and elongin A(Figs 2,3). The possible roles of the SOCS box in SH2-domain-containing SOCS proteins such as SOCS-1 and SOCS-3, and in the VHLprotein, elongin Aand Neuralized, are discussed in the following text. To date, 18 Asb genes have been identified in

Jan 1, 1998 · Structurally, the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box.

Feb 23, 2012 · The SOCS box is found in a diverse array of intracellular signalling molecules, many of which contain different protein interaction domains such as SPRY and WD40 domains, leucine and ankyrin repeats or other functional domains such as GTPases.