Our study shows that Snail is stabilized by the TNF-α/NF-κB pathway through the induction of CSN2, which blocks the phosphorylation and ubiquitination of Snail by disrupting its binding to …

The review discusses the signaling pathways of Snail family proteins, their role in maintaining an aggressive behavior of a tumor cell, and prospects for the pharmacological regulation of EMT …

Snail1 has a pivotal role in the regulation of epithelial-mesenchymal transition (EMT), the process by which epithelial cells acquire a migratory, mesenchymal phenotype, as a result of its …

Jan 19, 2010 · The TNF-α induces protein stabilisation of Snail and β-catenin by inhibiting GSK-3β-mediated phosphorylation through NF-κB and Akt signalling pathways. It also induces …

Snail is a zinc-finger transcriptional repressor controlling EMT during embryogenesis and tumor progression. Through its N-terminal SNAG domain, Snail interacts with several corepressors …

Feb 16, 2010 · Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment. Tumour necrosis factor …

Aug 2, 2014 · Snail1 has a pivotal role in the regulation of epithelial-mesenchymal transition (EMT), the process by which epithelial cells acquire a migratory, mesenchymal phenotype, as …

Snail not only acts primarily as a key inducer of EMT but also plays an important role in cell survival, immune regulation and stem cell biology. This review focuses on the regulation of …

Feb 8, 2017 · Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cell survival under metabolic stress.

Feb 16, 2018 · BMP7 induces the transcription factor Snail to promote astrocytic differentiation in GSCs and suppress tumor growth in vivo. We demonstrate that Snail represses stemness in …