Aug 26, 2024 · Simvastatin belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvastatin is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

Mar 12, 2024 · How is this medicine (Simvastatin Tablets) best taken? Use this medicine (simvastatin tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Take in the evening. Keep taking this medicine (simvastatin tablets) as you have been told by your doctor or other health care provider, even if you feel well.

May 16, 2024 · Simvastatin is a prodrug, which means it is converted into its active beta-hydroxyacid form, after administration. Peak levels are seen within 1.3 to 2.4 hours following administration; however, it may take up to one to two weeks of regular dosing before improvements in lipid levels are seen.

May 6, 2024 · You should not drink grapefruit juice with simvastatin because it can significantly increase blood levels of simvastatin and increase the risk of side effects such as liver damage and a condition called rhabdomyolysis, which is the excessive breakdown of muscle tissue. Occasionally, rhabdomyolysis can cause kidney damage and death. Continue reading

Dec 3, 2024 · 35. Ramdass MJ, Singh G, Andrews B (2007) "Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism." Postgrad Med J, 83, p. 152-3. 36. Molden E, Andersson KS (2007) "Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients." Pharmacotherapy, 27, p. 603-7. 37.

Oct 17, 2024 · Simvastatin tablets USP are indicated: ()To reduce the risk of total mortality by reducing risk of coronary heart disease death, non-fatal myocardial infarction and stroke, and the need for coronary and non-coronary revascularization procedures in adults with established coronary heart disease, cerebrovascular disease, peripheral vascular disease, and/or diabetes, who are at high risk of ...

Jul 2, 2024 · Simvastatin 80 mg dose should only be used in patients who have taken this dose chronically (e.g., for 12 months or more) without evidence of muscle toxicity If a patient on simvastatin 80 mg/day needs to initiate an interacting drug (one that will increase simvastatin concentrations); simvastatin should be switched to an alternative statin ...

Oct 10, 2024 · Increased simvastatin and simvastatin acid peak plasma concentration and AUC; increased risk of myopathy and/or rhabdomyolysis when used with higher dosages of simvastatin. Weigh benefits against risks of concomitant use; if used concomitantly, do not exceed simvastatin dosage of 20 mg daily. Ticagrelor

Mar 5, 2024 · Two months after starting combination therapy with ezetimibe-simvastatin he noticed epistaxis that increased from a few drops every other day to profuse bleeding for 20 to 30 minutes daily. The patient reported initiation of ezetimibe-simvastatin as the only change in his treatment regimen in the past year.

For patients with severe renal impairment [creatinine clearance (CLcr) 15 – 29 mL/min], the recommended starting dosage of simvastatin is 5 mg once daily. Use another simvastatin product to initiate dosing in such patients. There are no dosage adjustment recommendations for patients with mild or moderate renal impairment.