Mar 30, 2025 · Complete information for SERPINB7 gene (Protein Coding), Serpin Family B Member 7, including: function, proteins, disorders, pathways, orthologs, and expression.

The MEROPS online database for peptidases and their inhibitors: I04.012 SERPINB7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Jul 21, 2022 · SerpinB7 is identified as a skin-specific endogenous protease inhibitor, but the role and underlying mechanism in psoriasis are poorly understood. Here we found that SerpinB7 is highly...

SERPINB7 mutation causes Nagashima-type palmoplantar keratosis and its spatiotemporal expression in zebrafish. SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction.

Nov 7, 2013 · We performed whole-exome and/or Sanger sequencing analyses of 13 unrelated NPPK individuals and identified biallelic putative loss-of-function mutations in SERPINB7, which encodes a cytoplasmic member of the serine protease inhibitor superfamily.

Jul 22, 2022 · SerpinB7 is identified as a skin-specific endogenous protease inhibitor, but the role and underlying mechanism in psoriasis are poorly understood. Here we found that SerpinB7 is highly expressed in psoriatic keratinocytes of patients and imiquimod-induced psoriatic lesions in …

Dec 5, 2023 · In this study, we showed that SERPINB7 deficiency impaired the skin barrier and weakened cytoskeletal proteins such as intermediate filaments in Serpinb7 -knockout (Serpinb7−/−) mice.

SERPINB7 - serpin family B member 7 Synonym (s): MEGSIN, megsin Previous symbol (s) and name (s): serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7, serpin peptidase inhibitor, clade B (ovalbumin), member 7 Type: gene with protein product Chromosomal location: 18q21.33 OMIM: 603357 HGNC: 13902 UniProtKB: O75635 Genatlas ...

Nov 3, 2014 · Using RACE and PCR, they cloned SERPINB7 cDNA, which encodes a 380-amino acid protein that has 38% sequence identity to the serpin plasminogen activator inhibitor type 2 (173390). Mesangial cells play an important role in maintaining the structure and function of the glomerulus and in the pathogenesis of glomerular diseases.

SERPINB7 was found to be a crucial regulator of CESC progression, prognosis, and the tumor immune microenvironment, highlighting its potential as a diagnostic and prognostic biomarker and target for CESC immunotherapy. Keywords: Serpin family-B member 7, Cervical neoplasms, Prognosis, Tumor microenvironment, DNA methylation. 1. Introduction.