Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene. [5] It is primarily expressed in hematopoietic cells and endothelial cells, [6] and is the only known intracellular proteoglycan. [7]

Serglycin is a proteoglycan found in hematopoietic cells and endothelial cells. It has important functions related to formation of several types of storage granules.

Oct 2, 2007 · Serglycin is a proteoglycan found in hematopoietic cells and endothelial cells. It has important functions related to formation of several types of storage granules.

It has been shown that serglycin is highly expressed by tumor cells and promotes their aggressive phenotype and confers resistance against drugs and complement system attack. Apart from its direct beneficial role to tumor cells, serglycin may promote the inflammatory process in the tumor cell microenvironment thus enhancing tumor development.

Serglycin is a proteoglycan that has its core peptide coded by the gene SRGN in humans. It belongs to a family of small proteoglycans with serine-glycine dipeptide repeats and is modified with various glycosaminoglycan side chains.

Mar 30, 2025 · SRGN (Serglycin) is a Protein Coding gene. Diseases associated with SRGN include Mucinoses and Central Corneal Ulcer . Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Nuclear receptors meta-pathway .

Jan 2, 2024 · We identify fibrotic late-stage nucleus pulposus cells characterized by upregulation of serglycin expression which facilitate the local inflammatory response by promoting the infiltration of...

Nov 15, 2011 · Based on these findings, serglycin is emerging as a structural and functional chameleon, with radically different properties depending on its exact cellular and immunological context. Among the different proteoglycans expressed by mammals, serglycin is in most immune cells the dominating species.

Serglycin is a proteoglycan composed of a relatively small (~17 kDa) core protein to which sulfated glycosaminoglycans of either heparin, heparan sulfate or chondroitin sulfate types are attached. Serglycin is expressed in many cell types, including in …

Sep 23, 2021 · Here we show that the proteoglycan Serglycin (SRGN) secreted by neoplastic stromal cells plays a crucial role in the formation of MGCs and tumorigenesis in GCTB.