Sal-like protein 4 (SALL4) is a transcription factor encoded by a member of the Spalt-like (SALL) gene family, SALL4. [5][6] The SALL genes were identified based on their sequence homology …

After birth, SALL4 expression is down-regulated and absent in most adult tissues. However, SALL4 is re-expressed in various cancers. This review summarizes our current knowledge …

Mar 30, 2025 · SALL4 (Spalt Like Transcription Factor 4) is a Protein Coding gene. Diseases associated with SALL4 include Duane-Radial Ray Syndrome and Ivic Syndrome. Among its …

Restored SALL4 expression in adult tissues promotes cell proliferation, survival, invasion, migration, angiogenesis, and stemness and inhibits apoptosis through the regulation of its …

SALL4, a member of the SALL family, is an embryonic stem cell regulator involved in self-renewal and pluripotency. Recently, SALL4 overexpression was found in malignant cancers, including …

Feb 14, 2024 · Herein, this study indicates that the METTL3/SALL4 axis promotes the CSCs phenotype and resistance to radiation in OSCC via the Wnt/β-catenin signaling pathway, and …

Feb 1, 2015 · Gain- and loss-of-function studies reveal that SALL4 regulates proliferation, apoptosis, invasive migration, chemoresistance, and the maintenance of cancer stem cells …

Jan 3, 2018 · SALL4 is one of four human homologues (SALL1, 2, 3, and 4) of the Drosophila region-specific homeotic gene spalt (sal) [1, 2, 3, 4]. SALL4 encodes multiple Cys2His2 zinc …

A SALL4 zinc finger missense mutation predicted to result in increased DNA binding affinity is associated with cranial midline defects and mild features of Okihiro syndrome.

SALL4 is considered as a promising diagnostic and prognostic biomarker and therapeutic target for cancer. In this review, we highlighted the major advances in the roles and mechanisms of …