Accumulation of amyloid precursor protein C-terminal fragments …
a SDS-PAGE of C99 and C83 expression detected using APP-Cter antibody in mitochondria-enriched fraction of hippocampi of 5-month-old wild-type (WT) or 3xTgAD females treated …
A key role for MAM in mediating mitochondrial dysfunction in …
C99 is present in MAM, and accumulates above normal levels in AD cells and animal models. Increased C99-mediated MAM activity induces bioenergetic dysfunction in AD cells. Open …
Is γ-secretase a beneficial inactivating enzyme of the toxic APP C ...
Oct 9, 2020 · In this review, we summarize scientific evidences pointing to C99 as an early contributor to AD and postulate that γ-secretase should be considered as not only an Aβ …
The C99 domain of the amyloid precursor protein resides in the …
The cleavage of APP by β-secretase to generate the transmembrane 99-residue C-terminal fragment (C99) and subsequent processing of C99 by γ-secretase to yield amyloid-β (Aβ) …
The Pursuit of the “Inside” of the Amyloid Hypothesis—Is C99 a ...
Jan 31, 2023 · One of the APP metabolites, the 99-amino acids C-terminal fragment (C99, also called βCTF), is a direct precursor of Aβ and accumulates in the AD patient’s brain to …
MAM and C99, key players in the pathogenesis of ... - ScienceDirect
Jan 1, 2020 · Most AD cases are sporadic (SAD), characterized by the inheritance of genetically determined risk factors or polymorphisms that do not singlehandedly cause AD but rather …
The C99 domain of the amyloid precursor protein is a ... - bioRxiv
Nov 25, 2020 · Biochemical evidence suggests amyloidogenic processing of C99 occurs in cholesterol- and sphingolipid-enriched liquid ordered phase membrane raft domains. However, …
C99, not beta-amyloid, is associated with selective death of ... - bioRxiv
Jan 22, 2019 · We developed a sensitive assay adapted to the detection of C99, an intermediate in the conversion of APP to beta-amyloid. Brain tissue sections were obtained from patients …
We have approached this problem by adapting the proximity ligation assay (PLA) for the detection of C99. In this assay, two primary antibodies recognize the target epitopes on the protein of …
APP-CTFs accumulate in SAD brains and are associated with basal...
Download scientific diagram | APP-CTFs accumulate in SAD brains and are associated with basal mitophagy failure. a SDS-PAGE of full-length APP (APP), C99, C83, and Aβ expression in …
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