Feb 15, 2008 · Enhanced expression and activation of STAT1 and decreased claudin-5 were observed in microvessels from autopsied brains of patients with HIV-1–associated dementia. …

The PPI network was identified, and two modules linked through STAT1 were identified. It was finally determined that multiple biological pathways mediated by STAT1 may affect the …

Apr 3, 2024 · Li and colleagues report that cytokines IFN-γ and TNF-α can elicit a potent immunosuppressive function in adipose tissue-derived stem cells while inhibiting their …

We analyzed the STAT1 ChIP-Seq dataset of IFNγ-stimulated HeLa S3 cells derived from the ENCODE project, along with transcriptome analysis on microarray. We identified 1,441 …

Jul 27, 2017 · Our study identifies STAT1 methylation on K525 catalyzed by the methyltransferase SETD2 as an essential signaling event for IFNα-dependent antiviral …

Jan 27, 2006 · These investigators used RNA polymerase II (Pol II) to express a short hairpin RNA (shRNA) that triggers destruction of the mRNA-encoding Mn superoxide dismutase …

Jul 23, 2024 · Our findings revealed that EMPA mitigates cardiac inflammation and aging in HFpEF mice by inhibiting STAT1 activation. The STAT1–STING axis may act as a pivotal …

STAT2 was ruled out as a target of NS1 interference using quantitative Western blot analysis of infected A549 cells, but data were obtained to indicate that STAT1 was one of a number of …

Apr 19, 2017 · SOD2,[Citation 37] MX1,[Citation 38] ISG15,[Citation 39] SAMHD1 [Citation 40] and STAT1 [Citation 41] are all known to be upregulated in response to TNF. SQSTM1 has …

May 1, 2012 · This finding focused attention on SOD2 for downstream aspects of the present study because of potential implications for regulation of oxidative stress during hRSV infection …