Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family. [5]

Mar 30, 2025 · STAT1 (Signal Transducer And Activator Of Transcription 1) is a Protein Coding gene. Diseases associated with STAT1 include Immunodeficiency 31C and Immunodeficiency …

STAT1 is the major mediator of the cellular response to interferons (IFNs) [4, 5]. It plays a key role in the immune response against viruses and mycobacteria by transducing in the nucleus the …

Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, …

Nov 26, 2021 · JAKs are noncovalently associated with cytokine receptors, mediate tyrosine phosphorylation of receptors, and recruit one or more STAT proteins. Tyrosine-phosphorylated …

The STAT1 gene provides instructions for making a protein that is involved in multiple immune system functions, including the body's defense against a fungus called Candida . Learn about …

A monoclonal STAT1 N-terminal antibody (indicated as STAT1-N) was used to visualize the STAT1–STAT3 chimeric protein. A STAT3 C-terminal antiserum (indicated as STAT3-C) was …

STAT1 transduces signals from cytoplasmic domains of transmembrane receptors into the nucleus where it regulates gene expression. Thereby it modulates diverse cellular processes, …

Apr 7, 2022 · The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the immune response against viruses and other pathogens by transducing, in the …

Mar 18, 2025 · To antagonize IFN signaling, P-protein interacts directly with STAT1 through its P-CTD . Note that the efficient interaction of P-protein with STAT1 in cells depends on activation …