The Role of IL-33/ST2 in COPD and Its Future as an Antibody …
Here we summarize the current knowledge on the IL-33/ST2 pathway and its involvement in COPD, with a special focus on developed antibodies and the ongoing clinical trials using anti …
Astegolimab, an anti-ST2, in chronic obstructive pulmonary …
Mar 24, 2022 · In patients with moderate-to-very severe COPD and a history of frequent exacerbations, treatment with astegolimab, a novel anti-ST2 monoclonal antibody, did not …
Oxidised IL-33 drives COPD epithelial pathogenesis via ST2
Sep 28, 2023 · Our study reveals for the first time that IL-33, RAGE and EGFR act together in an ST2-independent pathway in the airway epithelium and govern abnormal epithelial remodelling …
IL-33 in COPD: the hunt for responder subgroups
Mar 24, 2022 · In The Lancet Respiratory Medicine, Ahmed Yousuf and colleagues 8 report a 48 week phase 2a trial of astegolimab, a monoclonal antibody against ST2, in 81 patients with …
Soluble ST2 and All-Cause Mortality in Patients with Chronic ...
Interleukin (IL)-33 and its decoy receptor, soluble suppression of tumorigenicity 2 (sST2), play a central role in the inflammatory response during infection. sST2 was suggested as a factor in …
Astegolimab study reports improved quality of life in patients with COPD
Mar 30, 2022 · The COPD-ST2OP trial took place at the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre – a partnership between Leicester’s Hospitals, …
We aimed to determine whether astegolimab, a selective ST2 IgG2 monoclonal antibody, reduces exacerbations in COPD. Methods COPD-ST2OP was a single-centre, randomised, double …
Astegolimab, an anti-ST2, in chronic obstructive pulmonary …
The epithelial-derived IL-33 and its receptor ST2 have been implicated in airway inflammation and infection. We aimed to determine whether astegolimab, a selective ST2 IgG2 monoclonal …
The Role of IL-33/ST2 in COPD and Its Future as an Antibody
May 12, 2023 · Here we summarize the current knowledge on the IL-33/ST2 pathway and its involvement in COPD, with a special focus on developed antibodies and the ongoing clinical …
Role of IL-33-ST2 pathway in regulating inflammation: current …
Dec 11, 2023 · In this review, we focused on the role of the IL-33-ST2 axis in sepsis, asthma, and COPD and summarized the therapeutic targets associated with this axis, providing a basis for …