Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6. [5][6] A related pseudogene has been identified on chromosome 1. Alternative splicing of this gene results in multiple transcript variants. [5] .

We will review SOD2’s potential involvement in the progression of neurodegenerative disease such as stroke, Alzheimer’s, Parkinson’s, as well as its potential role in “normal” age-related cognitive decline.

Superoxide anion is dismutated by superoxide dismutases (SODs) to H 2 O 2 that is catalyzed to H 2 O by catalase, peroxiredoxins (Prxs), or glutathione peroxidases (GPx) (Fig. 1).

Feb 10, 2025 · Several studies suggest SOD supplementation (such as VARS SOD) may improve symptoms in arthritis patients by reducing oxidative markers. Since SOD gene variations can impact antioxidant defenses, genetic testing can help identify potential weaknesses in SOD1, SOD2, or SOD3 function. If certain SNPs are present, individuals may need:

The Sod2 protein has been shown to be involved in a range of physiological and pathological processes. For example, the Drosophila sod2 mutant (SOD2 Bewildered) exhibits aberrant brain morphology, abnormal axonal targeting, and neurodegeneration (Celotto et al., 2012).

Aug 27, 2023 · SOD2 is encoded by nuclear genes and is initially transcribed in the cytoplasm as a larger precursor. Subsequently, it binds to transport stimulators on the mitochondrial membrane by signal peptides, undergoes mitochondrial treatment to remove N-terminal lead peptides, and becomes a mature protein.

Mar 17, 2022 · SOD2 V16A is associated with clinical markers of endothelial dysfunction in sickle cell patients. SOD2 V16A drives increased reactive oxygen species through decreased mitochondria complex IV activity.

However, our own observation from immunofluorescence preparations of human and mouse tissues suggested that SOD2 serves as an excellent marker protein for mitochondria but never co-localized with peroxisomes.

Identification of the regulatory network and potential markers for type 2 diabetes mellitus related to internal exposure to metals in Chinese adults. The role of SOD2 and NOS2 genes in the molecular aspect of bladder cancer pathophysiology.

SOD2 can provide some useful information of oxidative stress. However, SOD2 increases under mild or moderate oxidative stress while decreases in responding severe or prolonged oxidative...