Explore how SOD2 influences tumor metabolism through its role in oxidative stress regulation, expression changes in cancer cells, and metabolic adaptations. Superoxide dismutase 2 …

We propose that mitochondrial superoxide dismutase (SOD2) is a major system converting diffusion-restricted superoxide radicals derived from the electron transport chain into highly …

While much is known about the transcriptional regulation of the SOD2 gene, including downregulation by epigenetics and activation by stress response transcription factors, further …

Superoxide anion is dismutated by superoxide dismutases (SODs) to H 2 O 2 that is catalyzed to H 2 O by catalase, peroxiredoxins (Prxs), or glutathione peroxidases (GPx) (Fig. 1).

May 5, 2013 · In this review, we will specifically address epigenetic mechanisms underlying SOD2 transcriptional regulation, the metabolic consequences of SOD2 loss on cellular biology, and …

Feb 9, 2015 · Superoxide radicals in mitochondria are removed by the mitochondrial enzyme superoxide dismutase 2 (SOD2 aka manganese superoxide dismutase), generating hydrogen …

SOD2 uses cyclic proton-coupled electron transfer reactions to convert superoxide (O 2•-) into either oxygen (O 2) or hydrogen peroxide (H 2 O 2), depending on the oxidation state of the …

May 20, 2013 · Important recent advances in epigenetics research have indicated that the loss of SOD activity itself may contribute to changes in epigenetic regulation, establishing a vicious …

We therefore determined the impact of a high superoxide environment on cell size, progression through the cell cycle, cell differentiation, and cell death and found no difference between …

Using cDNA oligo gene expression microarray, we identified SOD2 (superoxide dismutase 2) as a potential CD44-downstream transcriptional target involved in BC metastasis. SOD2 gene …