Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. [5] [6] [7] This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as …

Jan 1, 2016 · Here, we focus on SOCS2 and review its biological function as well as its implication in pathological processes. Furthermore, we take advantage of the known crystal …

Mar 30, 2025 · SOCS2 (Suppressor Of Cytokine Signaling 2) is a Protein Coding gene. Diseases associated with SOCS2 include Hematologic Cancer and Polycythemia Vera. Among its …

SOCS2 impairs IFN/JAK/STAT signaling through reducing the stability of tyrosine kinase 2 (TYK2), downregulating the expression of type I and III IFN receptors, attenuating the …

SOCS2, an exciting therapeutic target, is indispensable in regulating inflammatory responses. SOCS2’s functionality as a suppressor of cytokine signalling lies predominantly in its ability to …

Dec 9, 2023 · We found that SOCS2 was a gene down-regulated in hepatoblastoma and associated with HB metastasis through bioinformatics. The qRT-PCR, Western blot and IHC …

Aug 22, 2022 · In this study, the suppressor of cytokine signaling 2 (SOCS2) were screened out by RNA-seq and bioinformatics analyses as a potential prognosis predictor of HCC …

SOCS2 was found to bind 2 phosphorylated tyrosines on the GH receptor, and mutational analysis of these amino acids showed that both were essential for SOCS2 function. Together, …

Sep 16, 2021 · SOCS1–3 and CISH are most closely involved in the regulation of immune-related signaling, influencing processes such polarization of lymphocytes and the activation of myeloid …

Specific studies targeting the SOCS genes in vivo have unveiled SOCS2 as the main regulator of somatic growth through regulation of GH/IGF-1 signaling. In addition, several studies indicate …