Membrane-associated transporter protein (MATP), also known as solute carrier family 45 member 2 (SLC45A2) or melanoma antigen AIM1, is a protein that in humans is encoded by the SLC45A2 gene. [5][6][7] In human, the SLC45A2 gene is located on the short (p) arm of chromosome 5 …

Mar 30, 2025 · Complete information for SLC45A2 gene (Protein Coding), Solute Carrier Family 45 Member 2, including: function, proteins, disorders, pathways, orthologs, and expression.

The SLC45A2 gene (also called MATP ) provides instructions for making a protein that is located in specialized cells called melanocytes. Learn about this gene and related health conditions.

Feb 8, 2025 · we propose that natural selection in South Europeans is favoring the allele SLC45A2 374F. High-resolution array-CGH in patients with oculocutaneous albinism identifies new deletions of the TYR, OCA2, and SLC45A2 genes …

The AIM1 gene encodes a melanocyte differentiation antigen that is expressed in a high percentage of melanoma cell lines. Its homolog in medaka fish, 'B,' encodes a transporter that mediates melanin synthesis (Fukamachi et al., 2001). SLC45A2 is an H (+)-dependent sugar transporter (Bartolke et al., 2014).

Sep 24, 2020 · SLC45A2 encodes a putative transporter expressed primarily in pigment cells. SLC45A2 mutations cause oculocutaneous albinism type 4 (OCA4) and polymorphisms are associated with pigmentation variation, but the localization, function, and regulation of SLC45A2 and its variants remain unknown.

Sep 18, 2024 · our study demonstrates the feasibility of using tandem MS as a means of discovering shared immunogenic tumor-associated epitopes and identifies SLC45A2 as a promising immunotherapeutic target for melanoma with high tumor selectivity and reduced potential for autoimmune toxicity

Dec 1, 2008 · The SLC45A2 gene encoding a transporter protein involved in melanin synthesis is considered to be one of the most important genes affecting human pigmentation.

This is the first time SLC45A2 has been described as a melanoma susceptibility gene in a light-skinned population. Human pigmentation appears to be one of the strongest risk factors for malignant melanoma (MM). In humans, there is a long list of genes known to be involved in rare pigmentary disorders such as albinism.

Chromosomal location: 5p13.2 OMIM: 606202 HGNC: 16472 UniProtKB: Q9UMX9 Genatlas: SLC45A2