Apr 13, 2019 · Here, we identified that transcriptional factor FoxO3a is a direct up-stream of SIRT6 and positively regulated SIRT6 expression, which in turn, promotes apoptosis by activating Bax and mitochondrial pathway.

Oct 11, 2013 · In this work we have discovered that Sirt6, an NAD + -dependent histone deacetylase, plays a critical role in the regulation of the Pcsk9 gene expression in mice. Hepatic Sirt6 deficiency leads to elevated Pcsk9 gene expression and LDL-cholesterol as well.

Apr 27, 2012 · First described as regulators of the aging process in invertebrate model organisms, Forkhead box “O” (FOXO) transcription factors and sirtuin deacetylases are now emerging as key regulators of mammalian vascular development and disease.

Feb 6, 2025 · SIRT6 is a NAD + -dependent histone deacetylase with crucial roles in controlling DNA damage repair, telomere homeostasis, oxidative stress, autophagy, and other cellular processes, and it has long been recognized as a longevity-associated protein. This review details its anti-aging-related …

In this study, we identified SIRT6 as a brand new transcriptional target of FoxO3a for the first time, and demonstrated Akt/FoxO3a/SIRT6 axis plays a crucial role in pro-apoptisis and colon cancer therapy by BKM120 both in vitro and in vivo. Lack of SIRT6 caused the resistance of colon cancer to BKM120 and combinational therapy.

Oct 11, 2013 · In this work we have discovered that Sirt6, an NAD(+)-dependent histone deacetylase, plays a critical role in the regulation of the Pcsk9 gene expression in mice. Hepatic Sirt6 deficiency leads to elevated Pcsk9 gene expression and LDL-cholesterol as well.

Jul 25, 2020 · Sirtuin 6 (Sirt6) is a highly conserved ADP-ribosylase and NAD+ dependent deacylase, involved in broad cellular processes. This molecule possesses contradictory roles in carcinogenesis, as it has been documented to both suppressing and augmenting tumor growth.

Hepatic deficiency of Sirt6 in mice leads to elevated cholesterol levels. On the mechanistic level, Sirt6 is recruited by forkhead box O (FoxO)3 to the Srebp2 gene promoter where Sirt6 deacetylates histone H3 at lysines 9 and 56, thereby promoting a repressive chromatin state.

Jun 17, 2014 · Cell-based assays demonstrate the p53-dependent nuclear exclusion of forkhead box protein O1 (FoxO1), a key transcription factor that mediates activation of PCK1 and G6PC, with consequent alleviation of FoxO1-dependent gluconeogenesis.

At vascular level, the physiological functions of SIRT1 and SIRT6 in the control of the cellular redox state are mediated by deacetylation of multiple targets, including histones, transcription factors (FOXO, NF-κB, p53, and Nrf2), and enzymes involved in the vascular protection.