NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 …

SIRT3 is a NAD+-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an …

Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism …

In characterizing the biochemical activity of SirT3, we show that both the full-length and processed forms of SirT3 have a strong NAD + -dependent histone deacetylation activity in vitro with …

Mar 30, 2025 · SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, …

Feb 6, 2014 · SIRT3, a major mitochondrial NAD + -dependent deacetylase, has a key role in cancer. The function of SIRT3 may be different depending on the cell-type and tumor-type; …

Apr 4, 2008 · Sirtuin 3 (SIRT3) a human homologue of Sir2, has been genetically linked to lifespan in the elderly. However, the function and localization of this enzyme has been keenly …

Jul 22, 2010 · Our results indicate that Sirt3 functions as a downstream target gene of PGC-1alpha and mediates the PGC-1alpha effects on cellular ROS production and mitochondrial …

SIRT3 regulates ketone body production by deacetylation of mitochondrial 3‐hydroxy‐3‐methylglutaryl CoA synthase 2 (HMGCS2), indicating its potential for …

Jul 9, 2020 · Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked …