Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and ...
Here, we review the up-to-date signaling pathways and molecular mechanisms by which SIRT3 regulates the biology of aging and age-associated diseases, especially cardiovascular and …
Mitochondrial Sirtuin 3: New emerging biological function and ...
Here we focus on summarizing the intricate mechanisms of SIRT3 in human diseases, and recent notable advances in the field of small-molecule activators or inhibitors targeting SIRT3 as well …
Sirtuin 3 - Wikipedia
NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 …
SIRT3: A Central Regulator of Mitochondrial Adaptation in Health …
SIRT3 is a NAD+-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an …
The sirtuin family in health and disease
Dec 29, 2022 · Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are …
Roles of SIRT3 in cardiovascular and neurodegenerative diseases
Feb 1, 2025 · SIRT3 protects against myocardial hypertrophy, heart failure, cardiac insufficiency. SRT3 impact neurodegenerative diseases by providing sufficient ATP to the brain. Sirtuin-3 …
The role of SIRT3 in homeostasis and cellular health
Aug 1, 2024 · SIRT3 substrates under homeostatic conditions: the schematic illustrates the various substrates and pathways regulated by SIRT3. (1) OXIDATIVE PHOSPHORYLATION: …
SIRT3 regulates mitochondrial function: A promising star target …
Jan 1, 2024 · SIRT3 regulates mitophagy through four pathways, including SIRT3- FOXO3a- PinK1/Parkin pathway, SIRT3-LKB1/AMPK/mTOR pathway, SIRT3-MnSOD2-ROS pathway. …
The Role of SIRT3 in the Brain Under Physiological and …
Jul 25, 2018 · Studies have suggested SIRT3 plays a vital role in all the major steps of this hepatic “glucose-sparing energy pathway”, as SIRT3 deacetylates and activates two key …
SIRT3, a mitochondrial NAD⁺-dependent deacetylase, is
Dec 9, 2014 · SIRT3 deacetylases and activates a large number of mitochondrial enzymes involved in the respiratory chain, in ATP production, and in both the citric acid and urea cycles. …