Sirtuins: Key players in obesity-associated adipose tissue remodeling
SIRT3 not only promotes brown adipocyte differentiation but also stimulates thermogenesis. SIRT3 reduces lipid droplet size and lipid accumulation by activating the AMPK pathway and …
Sirtuin 3: A major control point for obesity-related metabolic …
Jun 1, 2013 · Obesity is associated with decreased cellular NAD + concentration and decreased Sirt3 protein content, both of which likely contributed to attenuated Sirt3 activity. In turn, the …
Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity …
Mechanistically, SIRT3 inhibits mitochondrial calcium uniporter (MCU)-mediated mitochondrial calcium overload by reducing the H3K27ac level on the MCU promoter in an AMPK-dependent …
Mitochondrial Sirtuin 3: New emerging biological function and ...
Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism …
SIRT3: A Central Regulator of Mitochondrial Adaptation in Health …
SIRT3 is a NAD+-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an …
Mitochondrial dysfunction caused by SIRT3 inhibition drives ...
Mar 9, 2023 · Loss of SIRT3 in macrophages exacerbates HFD-induced obesity. To explore whether macrophage SIRT3 participates in obesity-related chronic inflammation, the …
SIRT3 deficiency-induced mitochondrial dysfunction and
Dec 3, 2018 · Downregulation of SIRT3 is a key component of metabolic syndrome, a precondition for obesity, diabetes and cardiovascular diseases. In this study, we examined the …
SIRT3 Ablation Deteriorates Obesity-Related Cardiac Remodeling …
The main mitochondrial deacetylase, SIRT3 participates in numerous cellular processes; however, its role in obesity-related cardiac remodeling remains unclear. In our study, high-fat …
SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts ...
Mar 22, 2016 · In this study, we found the impaired insulin-induced mesenteric vasorelaxation that is associated with reduced vascular SIRT3 expression in obese patients. We further identified …
Sirt3 prevents maternal obesity-associated oxidative stress
Together, our data identify Sirt3 as an important player in modulating ROS homeostasis during oocyte development, and indicate that Sirt3-dependent deacetylation of SOD2 plays a …