SZC-6, a small-molecule activator of SIRT3, attenuates cardiac
Aug 30, 2022 · In this study, we generated a novel SIRT3 activator, 3- (2-bromo-4-hydroxyphenyl)-7-hydroxy-2H-chromen-2-one (SZC-6), through structural optimization of the …
Small molecule natural compound agonist of SIRT3 as a …
Nov 12, 2018 · Here, we explored the expression of SIRT3 in IVDD in vivo and in vitro; we also explored the role of SIRT3 in senescence, apoptosis, and mitochondrial homeostasis under …
Sirtuin activators and inhibitors: Promises, achievements, and ...
The most potent compound, ELT-11c (Table 1), inhibits SIRT3 with an IC 50 of 4 nM, and SIRT3/ELT complex structures show that the inhibitors occupy C-pocket plus acetyl-Lys …
Icariside II, a Naturally Occurring SIRT3 Agonist, Protects against ...
Jul 27, 2022 · Furthermore, ICS II elevated the phosphorylation level of adenosine monophosphate-activated protein kinase (AMPK) and peroxisome proliferator-activated …
Mitochondrial Sirtuin 3: New emerging biological function and ...
Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism …
SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 ...
Jan 23, 2024 · In most cases, activating SIRT3 could be a promising strategy to tackle these health problems. Here, we summarize the main biological functions, substrates, and …
A review on SIRT3 and its natural small molecule activators as a ...
Jan 15, 2024 · Among the SIRT members, sirtuin 3 (SIRT3) is one of the most important deacetylases that regulates the mitochondrial acetylation and plays a role in pathological …
Rhynchophylline as an agonist of sirtuin 3 ameliorates endothelial ...
SIRT3-dependent mitochondrial homeostasis contributes to attenuating hypertension-related EPC dysfunction and endothelial injury, and Rhy itself is a potent and targeted SIRT3 agonist that …
Sirtuin 3: Emerging therapeutic target for cardiovascular diseases
Feb 20, 2022 · The current article focuses on the structure, subcellular location, and function of SIRT3, as well as the mechanisms underlying the mediation of cardiovascular disease by …
Structure-Guided Design of a Small-Molecule Activator of Sirtuin …
Oct 3, 2021 · In this study, we discovered a small-molecule activator of SIRT3 compound 33c (ADTL-SA1215) with specific SIRT3 deacetylase activity by structure-guided design and high …
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