Version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2) is the recommended tool to assess the risk of bias in randomized trials included in Cochrane Reviews. RoB 2 is structured into a fixed set of domains of bias, focussing on different …

Aug 22, 2019 · Welcome to the website for the RoB 2 tool. The current version (22 August 2019), suitable for individually-randomized, parallel-group trials. A version for cluster-randomized trials is now available (10 November 2020, revised 18 March 2021).

The Risk of Bias 2 (RoB 2) tool is an update to the original risk of bias tool that launched in 2008. The relevant chapter in the Cochrane Handbook for Systematic Reviews of Interventions Chapter 8, titled ‘Assessing risk of bias in a randomized trial’.

RoB 2 is called “results-based” or “results-level” because it is used to assess bias for a specific result reported in an individual study. The original risk of bias tool, and most other tools, assess bias across all outcomes and results for an entire study. Assessing bias for a specific result means that it is more precise.

Version 2 of the Cochrane tool for assessing the risk of bias in randomized trials (RoB 2), the updated version of the first tool, was released in 2019. Here, we have compared these two versions of Cochrane risk of bias assessment tools and highlighted the pros and cons of RoB 2.

• The revised tool for randomized trials (RoB 2.0) was supported by the UK Medical Research Council Network of Hubs for Trials Methodology Research (MR/L004933/1-N61)

Aug 28, 2019 · RoB 2 provides a framework for assessing the risk of bias in a single estimate of an intervention effect reported from a randomised trial. The effect assessed is a comparison of two interventions, which we refer to as the experimental and comparator interventions, for a specific outcome or endpoint. The process of making a RoB 2 assessment is ...

Aug 24, 2023 · The RoB 2.0 tool is for assessing the risk of bias in randomized controlled trials.

The RoB 2.0 assessment for individually randomized trials (including cross-over trials) has five domains, as follows. (1) Bias arising from the randomization process. (2) Bias due to deviations from intended interventions. (3) Bias due to missing outcome data. (4) Bias in measurement of the outcome. (5) Bias in selection of the reported result.

This chapter details version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2), the recommended tool for use in Cochrane Reviews. RoB 2 is structured into a fixed set of domains of bias, focusing on different aspects of trial design, conduct and reporting.