Lipopolysaccharide-induced Activation of NF-κB Non-Canonical …
In this report, we present new findings that demonstrate LPS activation of the non-canonical pathway of NF-κB activation in human colonic epithelial cells, leading to increased nuclear …
RELA - Wikipedia
RELA can either be phosphorylated in the RHD region or the TAD region, attracting different interaction partners. Triggered by lipopolysaccharide (LPS), protein kinase A (PKA) specifically …
NF-κB subunits direct kinetically distinct transcriptional ... - Nature
Jul 31, 2023 · Here we used time-dependent multi-omics to investigate the selective functions of Rel and RelA, two closely related NF-κB proteins, in primary B lymphocytes activated via the B …
IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages
Sep 11, 2014 · By intersecting the chromatin immunoprecipitation-sequencing (ChIP-seq) analysis of the individual TFs in LPS-stimulated GM-BMDMs with gene expression data and …
A Critical Role for the RelA Subunit of Nuclear Factor κB in …
We find that RelA activation by LPS or TNF-α and activation of the IFN-γ pathway are both required for activation of key genes involved in adaptive immune responses. In contrast, RelA …
The RelA/cRel nuclear factor-κB (NF-κB) dimer, crucial for
Lipopolysaccharide (LPS) modulates the transcription of the gene that codifies the enzyme arylalkylamine-N-acetyltransferase (AA-NAT) through nuclear translocation of the transcription …
Dissecting the Regulatory Strategies of NF-κB RelA Target Genes …
Feb 25, 2020 · We then dissected each gene’s regulatory strategy by testing RelA variants in a primary-cell genetic-complementation assay. All endogenous target genes require RelA to …
Deamidation Shunts RelA from Mediating Inflammation to …
May 5, 2020 · Compared to the mock-treated group, the deamidated species of RelA was detectably reduced in LPS-treated or SeV-infected groups (Figure S6 C). Consistent with NF …
American Journal of Respiratory Cell and Molecular Biology
Feb 5, 2002 · Acute inflammation induced by intrapulmonary LPS requires nuclear factor (NF)-κB RelA. This study elucidates the effects of intrapulmonary LPS on IκB proteins, endogenous …
MicroRNA-138 improves LPS-induced trophoblast dysfunction …
By binding the 3'-UTR of RELA, miR-138 negatively regulated p65 expression. The silencing of p65 also improved LPS-induced HTR-8/SVneo and JEG-3 cell dysfunction and TNF-α and IL …