Jun 15, 2018 · rb1 is necessary for neural precursor cell cycle exit and terminal differentiation, rbbp4 is required for survival of postmitotic precursors, and hdac1 maintains proliferation of the …

The non-coding RNA KTN1-AS1 binds to HDAC1 via RBBP4 in esophageal cancer to weaken the acetylation of histone H3 (ac-H3) at the promoter region of E-cadherin, thereby activating …

Our study provides novel insights into the tumor suppressive role of zebrafish Rb1 and its candidate interacting proteins Rbbp4 and Hdac1 in driving persistent tumor growth, and …

In this study, the expression of HDAC1 and RBBP4 was detected by IHC and western blot, and the correlation between HDAC1, RBBP4 and ER, PR, HER-2 was explored. We assess the …

May 24, 2024 · With a luciferase-based HDACI/II-activity assay, we measured robust HDAC activity in the eluates from HDAC1, SIN3B, and RBBP4 IPs (Fig. 3a).

Mar 1, 2020 · HDAC1 and RBBP4 were negatively correlated with ER and PR in BC, respectively. The patients with high expression of RBBP4 had a worse overall survival time. The expression …

Sep 1, 2024 · MTA1 brings two HDAC1/2 molecules and four RBBP4/7 molecules into the NuRD complex via its ELM2-SANT domain and C-terminus, respectively [76]. A central helical …

Jun 1, 2018 · Germline mutant analysis confirms that zebrafish rb1, rbbp4 and hdac1 are required during brain development. rb1 is necessary for neural precursor cell cycle exit and terminal …

Apr 14, 2020 · RBBP4 is essential during early embryo development in vivo, loss of RBBP4 results in defective inner cell mass (ICM), severe DNA damage and apoptosis, …

RBBP4 coexists with HDAC1 in deacetylase complexes that broadly deacetylatelysines (Johnson et al. 2002). One of these, the NuRD complex, where RBBP4, MTA1, and HDAC1 are core …