Nov 18, 2018 · Here, we describe a method of pinpoint press permeation to develop a rat SSS model and then evaluate its stability for investigating SSS pathogenesis. We also compare the survival rates, heart rate changes, histomorphological manifestation, and hyperpolarization-activated cyclic nucleotide-gated cation channel 4 (HCN4) protein expression levels ...

Jul 4, 2021 · In the present study, a novel Sprague-Dawley (SD) rat model of superior sagittal sinus (SSS) thrombosis was established via a thread-embolization method, and the stability and reliability of the model were verified.

Nov 18, 2018 · Here, we modified pinpoint press permeation to establish a stable rat SSS model. Methods: We randomly assigned 138 male Sprague-Dawley rats into three groups: normal control (n = 8), sham (n = 10), and SSS (n = 120).

Mar 1, 2019 · In this study, we use two methods to construct an SSS damage model in rats. One is to inject sodium hydroxide to the SSS area through internal jugular vein. Another is to cause ischemia-reperfusion injury on the SSS area. 43 healthy SD rats were randomly divided into 4 groups, namely ischemia-reperfusion injury group (IRIG), inject sodium ...

Sep 15, 2019 · In the present study, a new rat model of SSS occlusion was successfully established via a self-made thread embolism that was used to occlude the SSS. Compared with traditional models, our model can standardize the ischemic …

Nov 18, 2018 · Here, we describe our method of successfully inducing SSS by means of SAN damage in rats. Importantly, we also demonstrate that our model is sustainable and stable. Specifically, our data indicate that a 31–40% reduction in heart rate following SAN damage qualifies a stable rat SSS model.

To this end, our study aimed to identify a method to develop a stable rat SSS model. Several procedures to develop an SSS animal model have been reported, primarily involving physical or chemical impairment of the sinoatrial node (SAN).

Nov 18, 2018 · Sodium hydroxide pinpoint pressing permeation (SHPPP) was investigated in order to build a rat model of sick sinus syndrome (SSS), which is easy to operate and control the degree of damage,...

Sep 15, 2019 · The present study employed the insertion of a self-made thread embolism into the superior sagittal sinus (SSS) to establish a rat model of SSS occlusion that emulates CVST. The thread embolism was removed after 6 h of SSS occlusion in order to achieve recanalization.

Mar 1, 2019 · In this study, we use two methods to construct an SSS damage model in rats. One is to inject sodium hydroxide to the SSS area through internal jugular vein.