Oct 13, 2017 · Our results suggest that LPS infiltrates in the brain in physiological conditions, possibly, through a lipoprotein transport mechanism, and it is bound to its receptors in blood-brain interfaces....

We evaluated the suitability of an experimental lipopolysaccharide (LPS)-induced sepsis model for studying changes in the nociceptin system. C57BL/6 mice BALB/c mice and Wistar rats were inoculated with different doses of LPS with or without a …

Feb 15, 2024 · When TLR4 binds to LPS, it triggers a signaling cascade that activates various immune responses, including the production of pro-inflammatory cytokines. The recognition of LPS by TLR4 can activate the non-canonical caspase pathways, encompassing caspases-4/5 and caspase-11, and damage the cell membrane.

The LPS-treated rats demonstrated a significant deficit in temporal object recognition when compared with control rats (p < 0.0001). In a cued-recall paradigm, the LPS-treated rats were unable to temporally associate spatial events when presented in sequence on different days.

Feb 8, 2013 · Lipopolysaccharide (LPS) is widely used as septic model of ALI in pharmacological research. This study compares intratracheal bolus instillation (IT) with dose-adjusted aerosol inhalation (IH) of LPS in Wistar rats using both non-invasive and terminal endpoints.

In the present study, we used GC–MS coupled with univariate and multivariate analyses to elucidate the LPS-induced changes in metabolites occurring in the serum, liver, kidney, hippocampus, and heart of LPS-treated rats.

Sep 22, 2017 · Among the non-genetically manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal model is commonly used. This review paper aims to discuss the possible factors that influence rats' response following LPS injection.

Neonatal LPS exposure produces profound alterations in microglial morphology in the PFC in middle-aged male and female rats, indicating an activated state, and an effect that was evident months after challenge.

The present study aims to develop and standardize the effective concentration of Lipopolysaccharides (LPS) for induction of sepsis in male and female Sprague Dawley (SD) rat model as part of the refinement of animal protocols reducing pain and reduce stress in experimental rodents.

Oct 11, 2022 · We used two approaches (in vivo and ex vivo) to evaluate the effects of lipopolysaccharide (LPS)-induced neuroinflammation on neurometabolic reprogramming, and on the modulation of the glycolytic pathway during the neuroinflammatory response.