The receptor for advanced glycation end products (RAGE) is thought to be a primary transporter of beta-amyloid across the blood-brain barrier (BBB) into the brain from the systemic circulation, while the low-density lipoprotein receptor-related protein (LRP) …

Dec 4, 2023 · Our current research aims to shed light on the amyloid transport of the LRP1 and RAGE genes’ expression and, according to recent reports, also tau protein in post-ischemic neurodegeneration with long-term survival of up to 2 years [26,27,28].

RAGE plays an important role in the Aβ clearance. RAGE acts as an important transporter via regulating influx of circulating Aβ into brain, whereas the efflux of brain-derived Aβ into the circulation via BBB is implemented by LRP1.

LRP1 functions by promoting cellular uptake and degradation of AGE-modified proteins, helping to protect against oxidative damage and inflammation that arise from AGE accumulation. LRP1 is found in a variety of tissues, including the liver and vascular smooth muscle cells.

Jul 25, 2006 · To determine whether there are Alzheimer’s disease (AD)-related changes in these BBB-associated β-amyloid receptors, we studied RAGE, LRP-1, and β-amyloid in human elderly control and AD hippocampi. In control hippocampi, there was robust RAGE immunoreactivity in neurons, whereas microvascular staining was barely detectable.

Brain capillary endothelial cells are the key components of Aβ clearance mediated by BBB. Receptors (such as LRP1, RAGE, and FcRn) and ATP-binding cassette transporters (such as P-gp, ABCA1, and ABCC1) expressed on endothelial cells play a critical role in Aβ transcytosis across the BBB.

RAGE is known to mediate the influx of Aβ from blood to brain at the BBB, while LRP1 does the reversal to efflux Aβ from brain to blood. To determine Pb effect on RAGE and LRP1, ELISA was used to quantify the protein expression in the choroid plexus.

Jul 1, 2021 · LRP1 protects the vasculature by limiting remodeling events through the modulation of the TGF-β signaling pathway. LRP1 also plays an important role in the VEGF/VEGFR2/uPAR signaling under pathophysiological conditions, and is …

High cholesterol decreased LRP1 expression and increased RAGE expression in cerebral microvascular endothelial cells, which led to Aβ transport disorder in the blood-brain barrier. Increased Aβ deposition in the brain aggravated apoptosis in the brain, resulting to cognitive impairment of AD mice.

Apr 11, 2017 · Two major proteins, lipoprotein receptor-related protein (LRP-1) and receptor for advanced glycation end products (RAGE), are involved in receptor-mediated Aβ, trafficking across the blood-brain barrier (BBB). RAGE promotes an influx of circulating Aβ across the BBB from the blood to the brain, which is antagonized by LRP-1-mediated efflux of Aβ.