Jan 31, 2023 · Our results assign Rab2a and Rab7 to LEs and Arl8 and BORC to LYSs and show that HOPS drives LE-LYS fusion by bridging late endosomal Rab2a with lysosomal BORC …

Mar 1, 2011 · We summarize here the key protein interaction cascades of Rab7 by focusing on endo-lysosomal trafficking regulated by its interaction with HOPs, RILP, ORP1L, FYCO1 and …

Mar 16, 2020 · Mature or "late" endosomes are designated by small membrane-bound GTPases Rab7 and Arl8b, which can either operate independently or collaborate to form a joint …

Dec 2, 2014 · In this study, we report that RILP, a downstream effector of Rab7, interacts with HOPS complex and recruits HOPS subunits to the late endosomal compartment. Structurally, …

HOPS is required for the fusion of Rab7 + endosomes, a process initiated by HOPS-mediated membrane tethering and completed by the mechanical action of SNARE proteins and the …

Feb 20, 2018 · We found that CORVET and HOPS specifically interact with RAB5 and RAB7, respectively, and act in separate vacuolar trafficking pathways involving distinct sets of …

Oct 31, 2023 · It is known that homotypic fusion and vacuole protein sorting (HOPS) and class C core endosomal vacuole tethering (CORVET) interact with Rab-GTPases and SNARE proteins …

Jan 8, 2015 · PLEKHM1 appears to function as a platform that can link Rab7/HOPS to distinct cellular pathways, including endocytosis and autophagy, and has broad implications for the …

RAB7 activity regulates different pathways of endomembrane trafficking in plants: (1) endocytic traffic to the vacuole; (2) biosynthetic traffic to the vacuole; and (3) recycling from the late …

Mar 1, 2013 · Rab7 designates the maturation of endosomes and also autophagosomes, directing the trafficking of cargos along microtubules, and finally, participating in the fusion step with …