Jan 17, 2018 · Retromer is an endosomal multi-protein complex that organizes the endocytic recycling of a vast range of integral membrane proteins. Here, we establish an additional …

In order to modulate RAB7 activity and prevent lysosomal accumulation, retromer should co‐localize with RAB7 near lysosomal membranes. Thus, we next tested how retromer and …

The age-related retardation of female fertility was improved after in vivo treatment of ML098. Thus, RAB7 activity is required to maintain the balance between mitophagy and chromosome …

Rab7 (or Ypt7 in yeast) is one of the well-characterized members of the Rab family small GTPases, which serve as master regulators of membrane trafficking in eukaryotes. It localizes …

Mechanistic studies indicate that NRBF2 is required for autophagosome trafficking toward the lysosome via regulating RAB7 activity by interacting with GEF CCZ1-MON1A and facilitating …

Knocking down TBC1D5 increased the expression of active Rab7, promoted the fusion of lysosome and autophagosome, thus improving mitophagy, and improved the morphology of …

Nov 20, 2017 · RAB7 is known to be a key organizer/regulator of the late endosomal/lysosomal network that associates with various effectors to orchestrate diverse func-tions such as …

Jun 25, 2018 · The authors show that loss of TBC1D5 leads to increased levels of GTP-bound Rab7a, increasing the endosomal localisation of the retromer CSC and enhancing its …

Nov 20, 2017 · Retromer is an endosomal multi‐protein complex that organizes the endocytic recycling of a vast range of integral membrane proteins. Here, we establish an additional …

Jun 6, 2009 · To determine whether Rab7-Q67L could reverse the growth factor-independent cell survival of cells with reduced PKCδ activity, we introduced GFP-Rab7-Q67L into the cell lines …