Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome. [5] Its main function is the regulation of protein transport from the Golgi complex to the endoplasmic reticulum and the exocytosis along with the microtubules.

Mar 30, 2025 · RAB6A (RAB6A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB6A include Cohen Syndrome and Choroideremia . Among its related pathways are Rab regulation of trafficking and Innate Immune System .

Oct 6, 2020 · Rab6, the most abundant Golgi associated small GTPase, consists of 2 equally common isoforms, Rab6A and Rab6A′, that differ in 3 amino acids and localize to trans Golgi cisternae. The two...

In mouse brain, Rab6A immunostaining is found to be unexpectedly massive, diffuse in all regions, and is detected preferentially and abundantly in the peripheral astrocyte processes, which is hardly evident without glial fibrillary acid protein (GFAP) co-staining.

This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is …

ras-related protein Rab-6A, RAB6, member RAS oncogene family, Rab GTPase. RAB6A functions as a critical modulator of the stem-like subsets in cholangiocarcinoma. Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis.

RAB6A binds directly to OPN, and RAB6A KD suppressed OPN secretion and inhibited the interaction between OPN and αV integrin receptor. Moreover, RAB6A KD inhibited the AKT signaling pathway, which is a downstream effector of the integrin receptor signaling.

Mar 1, 2024 · RAB6A functions as a critical modulator of the stem-like subsets in cholangiocarcinoma. Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis. Rab6 regulates recycling and retrograde trafficking of MR1 molecules.

Apr 15, 2017 · Protein target information for Ras-related protein Rab-6A (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Feb 26, 2016 · Rab family GTPases have been well known to regulate intracellular vesicle transport, however their function in mammalian oocytes has not been addressed. In this study, we report that when Rab6a...