Mar 30, 2025 · RAB27A (RAB27A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB27A include Griscelli Syndrome, Type 2 and Griscelli Syndrome. Among its related pathways are MITF-M-dependent gene expression and Innate Immune System.

Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene. [5][6] The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction.

The RAB27A gene provides instructions for making a protein that is involved in a process called vesicle trafficking, which moves proteins and other molecules within cells in sac-like structures called vesicles. Learn about this gene and related health conditions.

Dec 10, 2024 · The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction.

In this study, by RNA interference technology, we investigated the effects of Rab27a gene silencing on the biological characteristics of NSCLC and its role as a potential target for lung cancer treatment.

These results show that RAB27A is a new direct transcriptional target of MITF and link MITF to melanosome transport, another key parameter of melanocyte differentiation and skin pigmentation. Rab27A is associated with invasive and metastatic potentials of …

Feb 8, 2025 · The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background. Rab27a regulates melanosome distribution in the retinal pigment epithelial cells.

Genes that were positively correlated with Rab27a in CGGA were analyzed by GO, and the results indicated Rab27a is involved in promoting proliferation, migration, cell activation, and angiogenesis and in the negative regulation of apoptosis.

Dec 6, 2009 · The small GTPases Rab27a and Rab27b and their effectors, Slp4 and Slac2b, control exosome secretion at different steps by regulating the peripheral localization, retention and docking of...

The studies indicated that Rab27a is a critical gene for organelle-specific protein trafficking in melanocytes and platelets and suggested that Rab27a functions in both MyoVa-dependent and -independent pathways.