Ras-related protein Rab-11B is a protein that in humans is encoded by the RAB11B gene. [5][6] Rab11b is reported as most abundantly expressed in brain, heart and testes. Rab (Ras-related in brain) proteins form the largest section of the Ras superfamily of small GTPases.

Untargeted proteomic profiling of Rab11a and Rab11b immunoprecipitates has uncovered a shared interactome containing mitotic spindle microtubule regulators. Disrupting Rab11 alters kinesin motor KIF11 function and impairs bipolar spindle formation and cell division.

Jul 1, 2019 · Rab11a and Rab11b knockout cell lines generated and novel functions identified. Both Rab11a and Rab11b contribute to the dynamics of the recycling endosomes. Rab11a plays a major role in the homeostasis of endosomal maturation. Deficiency of Rab11a results in a perturbation in endosome-TGN recycling of M6PR.

Jul 1, 2019 · Expression of wild-type Rab11a in Rab11a knockout cells rescued the late endosome/lysosome phenotype. Overall, these results indicate that Rab11a and Rab11b have overlapping and distinct functions and that Rab11a, unexpectedly, plays a central role in the homeostasis of endosomal-lysosomal biogenesis.

Rab11a or Rab11b silencing impairs LAMP1 cell-surface translocation and β-hexosaminidase release. HeLa cells transduced with lentiviruses encoding different shRNAs targeting Rab11a, Rab11b or both were treated with 10 μM ionomycin and 4 mM CaCl 2 for 10 min at 37°C to trigger lysosome exocytosis.

Jun 15, 2020 · Our results identify Rab11b-mediated recycling of integrin β1 as regulating BCBM, and suggest that the recycleome, recycling-based control of the cell surface proteome, is a previously...

Jan 30, 2025 · We generated an antibody against RAB11A and analyzed the distribution of RAB11A and RAB11B in mice. RAB11A was highly expressed in the ovary and the uterus but less abundant in the brain, whereas RAB11B was abundant in the …

Sep 14, 2018 · Misregulation of Rab11 isoforms is a key driver in oncogenesis (Rab25) and developmental diseases (Rab11A and Rab11B), and our work reveals insight into how Rab11 can be activated.

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene. [5][6] The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. [7]

Nov 1, 2023 · We confirm that disease-associated missense variants in RAB11B cause a neurodevelopmental disorder and suggest a genotype-phenotype correlation based on the impact on nucleotide binding functionality of RAB11B.