The inherent GTP hydrolysis of Rabs can be enhanced by a GTPase-activating protein (GAP) leading to Rab inactivation. REPs carry only the GDP-bound form of Rab, and Rab effectors, …

In this review article, we provide the most up‐to‐date and comprehensive lists of guanine nucleotide exchange factors, GTPase‐activating proteins, effectors, and knockout phenotypes …

Specific recognition of Rab proteins by GAP: Deactivation by stimulating GTP hydrolysis. Rab GAP proteins associate with a GTP-bound Rab and promote GTP hydrolysis, resulting in the …

Jul 15, 2009 · Rab GTPases control all aspects of intracellular vesicle trafficking by acting as regulatable switches that recruit effector molecules when in their active GTP-bound form. …

The GTP-bound Rab interacts with effector proteins that mediate membrane traffic in the pathway regulated by its associated Rab. The Rab then interacts with its associated GTPase activating …

The Rab family of small GTPases regulates intracellular membrane trafficking by orchestrating the biogenesis, transport, tethering, and fusion of membrane-bound organelles and vesicles. Like …

Rab proteins represent the largest branch of the Ras-like small GTPase superfamily and there are 66 Rab genes in the human genome. They alternate between GTP- and GDP-bound states, …

Aug 16, 2019 · Rab proteins compose the largest family of small GTPases and control the different steps of intracellular membrane traffic. More recently, they have been shown to also …

Feb 5, 2001 · In the GTP-bound form, the Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and …

Jan 1, 2002 · Recent studies of certain key regulators of vesicular transport, the Rab GTPases, have linked Rab dysfunction to human disease. Mutations in Rab27a result in Griscelli …