RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision.

Mar 30, 2025 · RBP1 (Retinol Binding Protein 1) is a Protein Coding gene. Diseases associated with RBP1 include Blepharophimosis and Endometrial Hyperplasia. Among its related pathways are Visual phototransduction and Diseases of the neuronal system. Gene Ontology (GO) annotations related to this gene include transporter activity and retinal binding.

Cellular retinol binding protein 1 transfection reduces proliferation and AKT-related gene expression in H460 non-small lung cancer cells. The RBP1-CKAP4 axis activates oncogenic autophagy and promotes cancer progression in oral squamous cell carcinoma.

Feb 8, 2025 · Gene target information for RBP1 - retinol binding protein 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Retinol-binding protein type 1 (RBP1) is an intracellular chaperone that binds retinol and retinal with high affinity, protects retinoids from non-specific oxidation, and delivers retinoids to specific enzymes to facilitate biosynthesis of RA. RBP1 expression is reduced in many of the most prevalent cancers, including breast cancer.

Feb 24, 2022 · Retinol-binding protein type 1 (RBP1) is an intracellular chaperone that binds retinol and retinal with high affinity, protects retinoids from non-specific oxidation, and delivers retinoids to specific enzymes to facilitate biosynthesis of RA. RBP1 expression is reduced in many of the most prevalent cancers, including breast cancer.

Oct 3, 2012 · RBP1, important in retinoic acid metabolism, was found to be hypermethylated in 76 of 79 IDH1 MUT, 3 of 3 IDH2 MUT, and 0 of 116 IDH1/IDH2 WT tumors. IDH1/IDH2 mutation was highly correlated with RBP1 hypermethylation (n = 198; Spearman R = 0.94, 95% confidence interval = 0.92 to 0.95, P < .001).

Feb 19, 2025 · Enables all-trans-retinol binding activity. Involved in lipid storage; maintenance of location in cell; and retinoid metabolic process. Acts upstream of or within regulation of granulocyte differentiation; response to vitamin A; and retinoid metabolic process. Located in …

Jan 23, 2007 · Gene Ontology (GO) annotations organized by slimming set. Showing features for mutagenesis. No effect on retinol binding. Abolishes interaction with STA6 and the ability to …

Jan 9, 2012 · HGNC Approved Gene Symbol: RBP1. Cytogenetic location: 3q23 Genomic coordinates (GRCh38) : 3:139,517,438-139,539,742 (from NCBI) Retinol-binding protein-4 (RBP4; 180250) is the carrier protein involved in the transport of retinol from the liver storage site to peripheral tissue.