Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene. [5][6] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family.

Mar 30, 2025 · PTPN21 (Protein Tyrosine Phosphatase Non-Receptor Type 21) is a Protein Coding gene. Diseases associated with PTPN21 include Prostate Cancer and Gastric Lymphoma. Among its related pathways are PAK Pathway and Signaling events mediated by …

Apr 4, 2019 · Knockout of Ptpn21 results in decreased cellular stiffness, enhanced deformability and motility, stem and progenitor cell egress, and defective hematopoietic reconstitution capabilities. Mechanistically, Ptpn21 modulates cell mechanics by …

Feb 28, 2024 · PTPN21 belongs to the four-point-one, ezrin, radixin, moesin (FERM) domain–containing protein tyrosine phosphatases (PTP) and plays important roles in cytoskeleton-associated cellular processes like cell adhesion, motility, and cargo transport.

Apr 4, 2019 · Hematopoietic stem cell (HSC) quiescence is a tightly regulated process crucial for hematopoietic regeneration, which requires a healthy and supportive microenvironmental niche within the bone marrow (BM). Here, we show that deletion of Ptpn21, a protein tyrosine phosphatase highly expressed in HSCs …

Feb 8, 2025 · PTPN21-CDSlong isoform inhibits the response of acute lymphoblastic leukemia cells to NK-mediated lysis via the KIR/HLA-I axis. Study demonstrates that PTPN21 activates KIF1C by binding to the stalk region.

PTPN21 belongs to the four-point-one, ezrin, radixin, moesin (FERM) domain-containing protein tyrosine phosphatases (PTP) and plays important roles in cytoskeleton-associated cellular processes like cell adhesion, motility, and cargo transport.

Feb 8, 2025 · The FERM domain of Ptpn21 stimulates dense core vesicle transport in primary hippocampal neurons and rescues integrin trafficking in Kif1c-depleted cells. PTPD1 is a component of a multivalent scaffold complex nucleated by FAK at specific intracellular sites

Ptpn21, a protein tyrosine phosphatase highly expressed in HSCs, plays an important role in maintaining cellular mechanics and HSC retention in the niche. Knockout of results in Ptpn21 decreased cellular stiffness, enhanced deformability and motility, stem and progenitor cell egress, and defective hematopoietic reconstitution capabilities.

Nov 23, 2023 · PTPN21-CDS_long isoform inhibits the response of acute lymphoblastic leukemia cells to NK-mediated lysis via the KIR/HLA-I axis. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia.