Mar 30, 2025 · PTPN14 (Protein Tyrosine Phosphatase Non-Receptor Type 14) is a Protein Coding gene. Diseases associated with PTPN14 include Choanal Atresia And Lymphedema and Lymphedema-Posterior Choanal Atresia Syndrome.

Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene. [5][6] The protein encoded by this gene is a member of the PTP family and PTPN14 subfamily of tyrosine protein phosphatases.

Aug 27, 2024 · PTPN14 overexpression exacerbates neointimal hyperplasia in a phosphatase activity-dependent manner, while SMC-specific deficiency of PTPN14 mitigates this process in mice. RNA-seq indicates...

Aug 27, 2024 · PTPN14 overexpression exacerbates neointimal hyperplasia in a phosphatase activity-dependent manner, while SMC-specific deficiency of PTPN14 mitigates this process in mice. RNA-seq indicates that PTPN14 deficiency inhibits PDGFRβ signaling-induced SMC phenotypic modulation.

PTPN14 is classified as a potential tumor suppressor protein, and is very susceptible to HPV E7-induced proteasome-mediated degradation. The Hippo signaling pathway was significantly associated with ER-negative breast cancer (pathway level P = 0.02).

Sep 25, 2020 · We demonstrated that PTPN14 promoted SOCS7 degradation through ubiquitination at K11 and K48 sites, thereby reducing SOCS7 at the protein level and weakening the inhibitory effects on...

Mar 10, 2023 · We found that PTPN14 was elevated in gastric cancer. Further correlation analysis indicated that PTPN14 was relevant with the T stage and cTNM (clinical tumor node metastasis classification)...

Title: PTPN14 acts as a candidate tumor suppressor in prostate cancer and inhibits cell proliferation and invasion through modulating LATS1/YAP signaling. PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by …

Dec 10, 2024 · PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

Jan 4, 2019 · HGNC Approved Gene Symbol: PTPN14. Cytogenetic location: 1q32.3-q41 Genomic coordinates (GRCh38) : 1:214,348,700-214,551,602 (from NCBI) Protein-tyrosine phosphorylation is regulated by the activities of the protein-tyrosine kinases (PTKs) and the protein-tyrosine phosphatases (PTPs).