Perhaps the earliest definitive example of such a pseudogene involved in cancer is the pseudogene of BRAF. The BRAF gene is a proto-oncogene that, when mutated, is associated with many cancers. Normally, the amount of BRAF protein is kept under control in cells through the action of miRNA.

4 days ago · A pseudogene is a segment of DNA that structurally resembles a gene but is not capable of coding for a protein. Pseudogenes are most often derived from genes that have lost their protein-coding ability due to accumulated mutations …

Pseudogene transcripts can be processed into short interfering RNAs that regulate coding genes through the RNAi pathway. In another remarkable discovery, it has been shown that pseudogenes are capable of regulating tumor suppressors and oncogenes by acting as microRNA decoys.

Welcome to Pseudogene.org! This site contains a comprehensive database of identified pseudogenes, utilities used to find pseudogenes, various publication data sets and a pseudogene knowledgebase. The website is developed and maintained by Yale Gerstein Group .

Dec 17, 2019 · Pseudogene–mRNA hybrids can be processed into small interfering RNAs (siRNAs), inhibiting parental gene expression.

Pseudogenes are evolutionarily conserved and derive primarily from a mutation or retrotransposon, conferring the pseudogene with a “gene repository” role to store and expand genetic information.

In our pseudogene survey, we have identified four CK19 processed pseudogenes on Chromosomes 4, 6, 10, and 12, which are almost all full length and have DNA sequence identities ranging from 62% to 85%.

This site contains a comprehensive database of identified pseudogenes, utilities used to find pseudogenes, various publication data sets and a pseudogene knowledgebase. Pseudogenes are genomic DNA sequences similar to normal genes but non-functional; they are regarded as defunct relatives of functional genes.

A pseudogene is defined as a genomic DNA sequence that looks like a mutated or truncated version of a known functional gene. Nearly four decades since their first discovery it has been estimated that between ~12,000 and ~20,000 pseudogenes exist in the human genome.

A pseudogene is a DNA sequence that resembles a gene but has been mutated into an inactive form over the course of evolution. Mammalian genomes harbor thousands of pseudogenes, and they account for approximately one-fourth of annotated genes in the human genome.