Feb 15, 2024 · As the core 5′TOP motif has been shown to be essential and sufficient for mTOR-dependent translational regulation, research has focused on studying the 5′TOP motif, and the function of the PRTE in contributing to this regulation remains to be determined.

Jun 8, 2022 · Furthermore, PRTE (pyrimidine-rich) motif is enriched in the 5′ UTRs of 4E-BP targets, and the translation of mRNAs with this motif are strongly inhibited after mTOR inactivation in both organisms.

Aug 14, 2024 · Our results indicate that P-eIF4E interfaces with the PRTE motif to regulate selective translation during fasting.

Genome-wide, we show that highly translated squamous cell carcinoma transcripts switch towards increased use of 5′TOP and PRTE motifs, have generally shorter 5′UTRs and expose decreased RNA...

Dec 23, 2022 · Genome-wide, we show that highly translated squamous cell carcinoma transcripts switch towards increased use of 5′TOP and PRTE motifs, have generally shorter 5′UTRs and expose decreased RNA secondary structures.

The search for consensus sequences from the first 20 nucleotides (nt) of target 5′UTRs identified a GGUCACACUG motif (dMotif-1) and a pyrimidine-rich motif (dPRTE; Fig. 1D).

We next tested whether a specific sequence or motif could be responsible for the translational regulation of Prps2. A recently identified, important eIF4E cis-regulatory element that confers translational specificity is the pyrimidine-rich translational element (PRTE) (Hsieh et al., 2012).

The PRTE motif is defined by the presence of uridine at position 6 surrounded by pyrimidines (5′-YYYYY U YYY-3′), and its location is not immediately adjacent to the 5′ cap [23].

PolyRibo-seq及突变实验揭示PRTE motif为关键顺式元件，响应P-eIF4E变化调控翻译。 体外模拟禁食条件的小鼠肝细胞系验证上述发现，表明 PRTE motif与P-eIF4E互作，在禁食期间介导mRNA选择性翻译。

The RPL32 5′UTR is 50 nucleotides in length and contains the 5′TOP motif (positions +1 to +11) as well as a pyrimidine-rich translational element (PRTE) at positions +38 to +47 (fig. S13A).