Jan 10, 2025 · Here we report a series of cryo-electron microscopy structures of AasS from the bioluminescent bacterium Vibrio harveyi to provide insights into the catalytic cycle. AasS forms a ring-shaped...

Dec 20, 2024 · A variety of early steps is committed to generate pimeloyl moiety as a fatty acid–like “arm” of biotin (i.e., an α,ω-dicarboxylic acid with seven carbons). Notably, the primary stage varies distinctly in diverse bacterial lineages.

May 30, 2014 · These findings suggest that RJPXD33 mimics the (R)-β-hydroxyacyl pantetheine moiety of acyl-ACP. This similarity to the acyl-PPan accounts for the dual targeting nature of RJPXD33 to both LpxA and LpxD, due to the fact that both enzymes utilize (R)-β-hydroxyacyl-ACP as a substrate.

(C) During the reaction, the ppan moiety (black) of CoA is transferred onto the carrier protein with 30,50-adenosine bisphosphate (gray) as a side product. In contrast to the two other types, PPTs from group II harbor two fused PPT domains within one protein (Lambalot et al., 1996).

An α-amino acid and a phenyl moiety protected the anionic phosphate group of Ppan and the terminal carboxylic acid of Ppan was a methyl ester, except in the case of Compound 8 where the isopropyl ester was prepared.

Phosphopantetheine Adenylyltransferase (PPAT) is an enzyme that catalyzes the penultimate step in the biosynthesis of Coenzyme A (CoA), which is the active and physiologically functional form of dietary Vitamin B5. You might find these chapters and articles relevant to this topic.

To address these problems, we report a self-assembled pentalysine-phthalocyanine assembly nanodots (PPAN) fabricated by an amphipathic photosensitizer-peptide conjugate. We triggered the PDT ...

Apr 24, 2014 · We investigated the impact of the residues involved on the velocity of the transfer reaction and the stability of the complex by performing a ppan transfer assay and isothermal titration calorimetry (ITC).

Clinical photosensitizers suffer from the disadvantages of fast photobleaching and high systemic toxicities due to the off-target photodynamic effects. To address these problems, we report a...

Energy minimization of this model of a productively docked PCP-E bidomain, where the 4’-Ppan moiety positions bound D-phenylalanine between H743 and E882, followed by relaxation using a molecular dynamics run by AMBER11 over 2 ns gave only minor structural deviations of …