Michael PIKAL | Cited by 15,441 | of University of Connecticut, CT (UConn) | Read 184 publications | Contact Michael PIKAL

Michael J. Pikal (August 17, 1939 – February 26, 2018) was an American pharmaceutical scientist. Pikal was born in Wadena, Minnesota, on August 17, 1939, to parents Harold and Sophie.

Feb 4, 2021 · It is the purpose of this review to discuss the scientific foundations of the freeze-drying process design and then to consolidate these principles into a set of guidelines for rational process design and optimization.

M. J. Pikal. Mechanisms of protein stabilization during freeze-drying and storage: the relative importance of thermodynamic stabilization and glassy state relaxation dynamics.

Pikal MJ, Rambhatla S, Ramot R. The impact of the freezing stage in lyophilization: effects of the ice nucleation temperature on process design and product quality.

Mar 30, 2014 · Lu X, Pikal MJ. Freeze-drying of mannitol-trehalose-sodium chloride-based formulations: the impact of annealing on dry-layer resistance to mass transfer and cake structure.

Bio: Pikal, Michael Jon, Apparent molal volumes and viscosities of some aqueous rare-earth chloride solutions at 25°C (1966). Retrospective Theses and Dissertations. 2873.

Oct 25, 2013 · Pikal MJ, Cardon S, Bhugra C, Jameel F, Rambhatla S, Mascarenhas WJ, et al. The nonsteady state modeling of freeze drying: in-process product temperature and moisture content mapping and pharmaceutical product quality applications.

Schneid SC, Gieseler H, Kessler WJ, Pikal MJ. Non-invasive product temperature determination during primary drying using tunable diode laser absorption spectroscopy.

M. J. Pikal. Mechanisms of protein stabilization during freeze-drying and storage: the relative importance of thermodynamic stabilization and glassy state relaxation dynamics.