An interesting study showed that NRG-4 overexpression prevents high fat diet-induced weight gain and fatty liver and reduces obesity-induced chronic inflammation.

The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation. [7] Loss of expression of NRG4 is …

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NRG-4 is released from brown adipose tissue and reduces pro-inflammatory activation of tissue-resident macrophages and their differentiation into foam cells. NRG-4 promotes endothelial …

Apr 28, 1999 · Here we report on a fourth neuregulin, denoted NRG-4, which acts through the ErbB-4 receptor tyrosine kinase. In addition to its novel structure, this growth factor displays a …

Mean levels of plasma neuregulin-4 (pg/mL) in newly diagnosed T2DM were 7949.76 ± 949.76) pg/ml, which was significantly lower as compared to 9143 ±949.76) pg/ml in the control group …

Apr 2, 2020 · Nrg4, a novel adipocytokine, has negative correlations with indicators of metabolic syndrome. Here, we investigated whether circulating Nrg4 associates with the prevalence of …

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Neuregulin-4 (Nrg4), a novel brown fat-enriched factor, has been reported to play a crucial role in developing metabolic disorders. The current case-control study aimed to investigate the …