Nov 1, 2022 · Oxidative stress from excess reactive oxygen species (ROS) is a hypothesized contributor to preterm birth. Per- and polyfluoroalkyl substances (PFAS) exposure is reported to generate ROS in laboratory settings, and is linked to adverse birth outcomes globally.

Dec 15, 2022 · Degradation pathways of PFAS are reliant on the type of dominant ROS. Catalysts of functional groups may anchor the COO – and facilitate decarboxylation. Holes oxidize PFCAs and PFSAs to unstable perfluoroalkyl radicals. FTCAs are more resistant than PFCAs of …

Seven long-chained PFAS found in human serum were investigated for the potential to generate reactive oxygen species (ROS), induce DNA damage and disturb the total antioxidant capacity (TAC).

Our results indicate that the generation of ROS may play a role in PFOS-induced aberrations of the endothelial permeability barrier. The results generated from this study may provide a new insight into the potential adverse effects of PFOS exposure on humans at the cellular level.

Apr 15, 2023 · Long-chain per- and polyfluoralkyl substances (PFAS) are ubiquitous contaminants implicated in the induction of intracellular reactive oxygen species (ROS), compromising antioxidant defense mechanisms in vitro and in vivo.

The individual and binary combination effects of PFAS on the cytotoxicity, intracellular reactive oxygen species (ROS) production, and glutathione (GSH) levels were determined by MTS assay, dichlorofluorescein diacetate assay, and GSH-Glo™ Glutathione assay, respectively.

In the present study we demonstrate several PFOA-mediated cell death pathways (necrosis/necroptosis, and apoptosis) and assess the roles of ROS-MAPK/ERK signaling in PFOA-mediated cell death in mouse ameloblast-lineage …

Six PFAS (except for PFDoA) increased ROS generation and the increase was dose-dependent for two PFAS (PFHxS and PFUnA). PFOA significantly decreased the total antioxidant capacity (TAC), whereas a non-significant trend in TAC decrease was observed for PFOS and PFDoA and an increase tendency for PFHxS, PFNA and PFUnA.

Apr 15, 2023 · Long-chain per- and polyfluoralkyl substances (PFAS) are ubiquitous contaminants implicated in the induction of intracellular reactive oxygen species (ROS), compromising antioxidant defense mechanisms in vitro and in vivo.

Feb 22, 2023 · By disturbing the Ca 2+ modulating function of mitochondria, PFAS may cause mitochondrial Ca 2+ overload and increase mitochondrial ROS, which further contributes to an affected immune response.