Phosphatidylethanolamine N-methyltransferase (abbreviated PEMT) is a transferase enzyme (EC 2.1.1.17) which converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. [5] [6] [7] In humans it is encoded by the PEMT gene within the Smith–Magenis syndrome region on chromosome 17. [8] [9]

Mar 30, 2025 · PEMT (Phosphatidylethanolamine N-Methyltransferase) is a Protein Coding gene. Diseases associated with PEMT include Cardiac Valvular Dysplasia 1 and Choline Deficiency Disease. Among its related pathways are Glycerophospholipid biosynthesis and One-carbon metabolism and related pathways.

Phosphatidylethanolamine N-Methyltransferase (PEMT) is an enzyme encoded for by the gene PEMT, which is responsible for the conversion of phosphatidylethanolamine (PE) into phosphatidylcholine (PC) in the liver 1.

May 11, 2016 · PEMT stands for phosphatidylethanolamine N-methyltransferase. That is quite a word! This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by methylation in the liver.

Phosphatidylethanolamine N -methyltransferase (PEMT) catalyzes phosphatidylcholine synthesis. PEMT knockout mice have fatty livers, and it is possible that, in humans, nonalcoholic fatty liver disease (NAFLD) might be associated with PEMT gene polymorphisms.

Phosphatidylethanolamine N -methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC). This 22.3 kDa protein is localized to the endoplasmic reticulum and mitochondria associated membranes of liver.

Feb 8, 2025 · The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.

Choline is an essential nutrient for humans, though some of the requirement can be met by endogenous synthesis catalyzed by phosphatidylethanolamine N -methyltransferase (PEMT). Premenopausal women are relatively resistant to choline deficiency compared with postmenopausal women and men.

Mar 1, 2024 · Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes.

The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.