Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. [5] [6] PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273). PDCD1LG2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response.

Mar 30, 2025 · PDCD1LG2 (Programmed Cell Death 1 Ligand 2) is a Protein Coding gene. Diseases associated with PDCD1LG2 include Hematologic Cancer and Leukemia, Acute Lymphoblastic. Among its related pathways are Phosphorylation of CD3 and TCR zeta chains and Innate Immune System. An important paralog of this gene is CD274.

Feb 8, 2025 · PDCD1LG2 (PD-L2) RNA in situ hybridization is a sensitive, specific, and practical marker of primary mediastinal large B-cell lymphoma. PD-L1 and PD-L2 are differentially expressed by macrophages or tumor cells in primary cutaneous diffuse large B …

Dec 15, 2022 · Programmed death ligand-2 (PD-L2), a PD-1 ligand, mediates cancer cell immune escape (or tolerance independent of PD-L1) and predicts poor prognosis of patients with HNSCC....

Jun 2, 2022 · Here we describe the genomic landscape of CD274 and PDCD1LG2 structural variations, their potential impact on the tumor microenvironment, and evidence that patients with these alterations can benefit from immunotherapy.

We examined tumor PDCD1LG2 expression by IHC in 823 colon and rectal carcinoma cases within two U.S.-nationwide cohort studies and categorized tumors into quartiles according to the percentage of PDCD1LG2-expressing carcinoma cells.

We examined tumor PDCD1LG2 expression by immunohistochemistry in 823 colon and rectal carcinoma cases within two U.S.-nationwide cohort studies and categorized tumors into quartiles according to the percentage of PDCD1LG2–expressing carcinoma cells.

PDCD1LG2 in KEGG analysis was implicated in TNF signaling pathway, Th1 and Th2 cell differentiation, NOD-like receptor signaling pathway, cell adhesion molecules (CAMs), Th17 cell differentiation, as well as chemokine signaling pathway (Supplementary Figure 3D).

Dec 17, 2023 · Gene target information for PDCD1LG2 - programmed cell death 1 ligand 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

PDCD1LG2, programmed cell death 1 ligand 2, encodes PD-L2, a ligand for PD-1, which upon interaction exert an inhibitory effect on immune response (PMID: 11224527, PMID: 26432723, PMID: 28018338).