Pax7 and MyoD interact with each other during myogenesis, making them ideal markers for determining the cells’ quiescent, activation and myogenic status. The Pax7 and MyoD proportions of satellite cell subpopulations have well-established symmetric expression patterns; Pax7+/MyoD−, Pax7+/MyoD+, and Pax7−/MyoD+ [ 44 , 46 , 47 ].

May 1, 2006 · Constitutive Pax7 expression in a Pax7-null C2C12 subclone increased the proportion of cells expressing MyoD, showing that Pax7 can act genetically upstream of MyoD. However these Pax7-null cells were unable to differentiate into …

To address whether other embryonic cell populations can serve as satellite cell progenitors when MyoD+ cells are ablated, we assessed Pax7 expression in MyoD lineage-ablated embryos.

We observed that the PAX7 protein expression level increased significantly after eccentric (47.75%) and concentric (39.21%) (P=0.01) intervention. While, the MyoD protein expression level reduced (38.14%) significantly following acute eccentric resistance exercise (P=0.01).

May 1, 2006 · Quiescent satellite cells express the transcription factor Pax7 and when activated, coexpress Pax7 with MyoD. Most then proliferate, downregulate Pax7 and differentiate. By contrast, others maintain Pax7 but lose MyoD and return to a state resembling quiescence.

We show that Pax3 and 7 participate in adult skeletal muscle plasticity during the initial responses to chronic overload (≤7 days) and appear to coordinate MyoD expression, a member of the MRF family of genes.

Sep 18, 2019 · PAX7 is a paired-homeobox transcription factor that specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation.

Aug 1, 2015 · Both factors are key regulators of myogenesis where Pax3 plays a major role during early skeletal muscle formation in the embryo while Pax7 predominates during post-natal growth and muscle regeneration in the adult. We review the expression and functions of these factors in the myogenic context.

Jun 28, 2022 · Molecularly, we showed that Myf5 and MyoD, the known downstream targets of Pax7, induce the expression of a transcription repressor E2f4 that in turn suppresses the lineage of brown adipocytes...

May 22, 2017 · We show that the Pax7-MyoD/Myf5-E2F4/p107/p130 axis serves as a key molecular switch in both the Pax7 + embryonic progenitor cells and postnatal myoblasts to repress the BA fate.