We report, for the first time, phosphorylation of multiple protein kinases, including Mitogen-activated protein kinase-activated protein kinase 2 (Mapkapk2), Receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1) and NAD kinase (Nadk) that are induced by IL-33.

Illustration shows the diverse cellular sources of interleukin (IL)-33, sensing of IL-33 by adaptive and innate immune cells, and the plethora of immunological and nonimmunological functions regulated by IL-33 to preserve immune and tissue homeostasis.

Interleukin-33 (IL-33) is a tissue-derived nuclear cytokine from the IL-1 family abundantly expressed in endothelial cells, epithelial cells and fibroblast-like cells, both during homeostasis and inflammation.

Using data mined from the published literature, we describe an integrated pathway reaction map of IL-33/IL-33R consisting of 681 proteins and 765 reactions.

Oct 10, 2019 · Our results reveal that JAK2/PAK1 dysregulation inhibits the Stat3 signaling pathway and CSC formation, the PAK1/Stat3 complex regulates IL-6 gene expression, PAK1/Stat3 signaling regulates CSC formation, and PAK1 …

Dec 11, 2023 · In response to cellular damage or stress, IL-33 is released and activates innate immune responses in some immune and structural cells via its receptor interleukin-1 receptor like-1 (IL-1RL1 or ST2). Recently, IL-33 has become a hot topic of research because of its role in pulmonary inflammation.

Jun 30, 2021 · Interleukin-33 (IL-33), a member of the IL-1 cytokine family, plays a critical role in maintaining tissue homeostasis as well as pathological conditions, such as allergy, infectious disease, and cancer, by promoting type 1 and 2 immune responses.

Interleukin 33 (IL-33) is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.

This study tests the hypothesis that activation of MAPK by physiologically relevant concentrations of IL-33 contributes to enhanced cytokine expression by IL-12 stimulated human NK cells. While IL-33 canonically triggers type 2 cytokine responses, ...

IL-33 enhances IL-12-induced cytokine expression in primary human NK cells. Enriched primary human NK cells were stimulated with combinations of IL-12 and IL-33 (doses listed in ng/ml) for 16 hours prior to ELISA determination of (A) IFN-γ, …