PP2A is one of the most well-studied phosphatases and has been implicated in the regulation of many cellular processes including cell cycle progression [48, 49], DNA replication, gene …

Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that regulates a diverse array of cellular processes. Here, utilizing both a gain-of-function chemical biology approach and …

Mec1 ATR mediates the DNA damage response (DDR), integrating chromosomal signals and mechanical stimuli. We show that the PP2A phosphatases, ceramide-activated enzymes, …

May 27, 2024 · Sch9 and PP2A emerge as key mediators in influencing the response to DNA damage during aging. These findings highlight a link between nutritional conditions and …

2 days ago · As PP2A:B55 orchestrates mitosis and DNA damage repair, these data provide a roadmap for pursuing new avenues to therapeutically target this complex by individually …

Oct 22, 2021 · PP2A is a major serine/threonine phosphatase class involved in the regulation of cell signaling through the removal of protein phosphorylation. This class of phosphatases is …

Feb 21, 2019 · In this review, we have compiled recent information about the function of protein phosphatases PP1, PP2A, PP4 and Cdc14 in the DDR, focusing mainly on their capacity to …

Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that regulates a diverse array of cellular processes. Here, utilizing both a gain-of-function chemical biology approach and …

Dec 1, 2021 · DNA replication stress activates the S-phase checkpoint that arrests the cell cycle, but it is poorly understood how cells recover from this arrest. Cyclin-dependent kinase (CDK) …

Protein phosphatase 2A regulatory subunit B55α (PP2A-B55α) is encoded by Ppp2r2a. Liang et al. found that PP2A-B55α was an important regulator of oocyte asymmetric division, …