Nov 27, 2007 · The oncoprotein polyoma small T interacts with PP2A to regulate survival. In the presence of growth factors, small T induces apoptosis. Akt activity, which usually promotes survival, is required for this death response, because …

Reduction of tau phosphorylation by inhibition of GSK-3β may be more than offset by inhibition of PP2A through a shift in phosphatase methylesterase-1/leucine carboxyl methyltransferase 1 balance; PP2A regulates phosphorylation of tau at Ser262/356, a required site for tau pathology.

Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine threonine phosphatase and regulates the function by dephosphorylating many critical cellular molecules like Akt, p53, c-Myc and β-catenin.

Oct 1, 2022 · This study indicated that PP2A could regulate VM formation in NSCLC through the PI3K/AKT/ZEB1 axis. PP2A reactivation or combination with PI3K inhibitor might be a more effective treatment against advanced NSCLC by inhibiting VM formation.

The PP2A-B55α Holoenzyme Preferentially Regulates the Phosphorylation of Akt at Thr-308 Downstream of IL-3 Stimulation in FL5.12 Cells—Given that the PP2A-B55α holoenzyme interacts with Akt, we investigated the impact of this association on Akt phosphorylation.

Jan 25, 2008 · We found endogenous association of PP2A AB55C holoenzymes with Akt by co-immunoprecipitation analyses in pro-lymphoid FL5.12 cells. Akt was shown to associate with ectopically expressed B55alpha subunit in NIH3T3 cells.

Dephosphorylated PPP2R5D promotes constitutive assembly of PP2A-AKT complex, therefore inhibits insulin-induced AKT phosphorylation and subsequent glucose uptake in both BAT and WAT. Knockdown of PPP2R5D in adipocytes can improve insulin sensitivity in adipocytes without SNRK expression.

We found that the inhibition of PP2A led to an elevation of the Akt phosphorylation level without affecting PI 3-kinase or PDK-1 activity, and these results suggest that PP2A may directly modulate Akt function.

Feb 18, 2011 · Here we show that a downstream target of insulin-induced Akt activation, Clk2, triggers Akt dephosphorylation through the PP2A phosphatase complex.

Mar 14, 2016 · Here we report a previously unrecognized requirement for the serine-threonine phosphatase PP2A in the function of T reg cells. T reg cells exhibited high PP2A activity, and T reg cell–specific...