Distinct Roles for the α, β and γ1 isoforms of Protein Phosphatase …
Three isoforms of PP1c that share ~90% amino acid sequence similarity have been identified and includes PP1cα, PP1cβ/δ and PP1cγ [6]. PP1cγ has two splice variants; PP1cγ1 (ubiquitous …
Structural Basis for Protein Phosphatase 1 Regulation and …
The ubiquitous Ser/Thr Protein Phosphatase 1 (PP1) regulates diverse, essential cellular processes such as cell cycle progression, protein synthesis, muscle contraction, carbohydrate …
Differential localizations of protein phosphatase 1 isoforms …
Protein phosphatase 1 isoforms α, β, and γ (PP1α, PP1β, and PP1γ) are highly homologous in the catalytic domains but have distinct subcellular localizations. In this study, we utilized both …
Combinatorial control of protein phosphatase-1 - Cell Press
Jul 1, 2001 · The sequence of the catalytic core of PP1 C (residues 41–269 of the mammalian α isoform) is nearly identical for all isoforms, and shows a high degree of similarity with the …
Regulation of protein phosphatase-1 - Cell Press
Jan 1, 2001 · The PP1-M holoenzyme consists of a heterotrimer containing PP1c (perhaps a specific isoform) [38], a large (110–130 kDa) subunit termed M 110 (also termed MYPT1) [39], …
ISOFORM–SPECIFIC ROLES OF PROTEIN PHOSPHATASE 1 …
The three PP1 catalytic subunits (α, β, and γ) have ~90% homology in the catalytic domains and unique N and C terminal sequences. The function of each isoform in the heart remains poorly …
Complex functionality of protein phosphatase 1 isoforms in the …
This review will summarize how PP1 regulates phosphorylation of some of the key cardiac proteins involved in Ca 2+ handling and cardiac contraction, and the potential role of PP1 …
PP1 catalytic isoforms are differentially expressed and regulated in ...
Sep 15, 2022 · Here we analyzed the expression and localization of the PP1 catalytic (PP1c) isoforms in formalin-fixed, paraffin-embedded prostate tissue samples, as well as in PCa cell …
Regulation of Cellular Protein Phosphatase-1 (PP1) by …
Oct 21, 2021 · The regulatory circuit controlling cellular protein phosphatase-1 (PP1), an abundant group of Ser/Thr phosphatases, involves phosphorylation of PP1-specific inhibitor …
Protein Phosphatase 1 beta is Most Abundant Isoform in the …
Immunoblotting for PP1 isoforms in junctional and longitudinal SR fractions revealed that PP1b was most abundantly enriched in the longitudinal SR fraction among the PP1 isoforms.