Typically, polyvinyl alcohol (PVA) is the most commonly used emulsifier or stabilizer to formulate PLGA microspheres. PVA is a semi-crystalline synthetic polymer, soluble in water and …

The amount of surfactant plays an essential role in the emulsification-solvent evaporation process, by the protection of the droplets containing the PLGA against coalescence. 65,66 Fig. 2B …

Dec 1, 2020 · During the preparation of PDLLA and PLGA NPs via a single emulsion method, electrosteric-like stabilization imparted by the PVA-SDS led to the formation of smaller …

Mar 15, 2021 · Here, we developed a tunable, stabilizer-free PLGA nanoparticle formulation capable of encapsulating plasmid DNA and demonstrated the formation of an elastin-like …

Polymeric nanoparticles (PNPs) are promising drug carriers in cancer treatment. Size of the particles has a significant impact on drug loading, in vivo distribution, extravasation, intratumor …

Sep 15, 2022 · For this reason, five different systems containing polymeric particles of poly [D, L–lactic–co–glycolic acid (PLGA)] were developed to encapsulate 5-ALA based on single and …

In our hands, we find that PVA is a more effective emulsifier at much higher concentrations than TPGS (e.g. diameter of 140 nm±48, 100 mg/ml PLGA in DCM, emulsified into 2 ml 5% PVA). …

Jul 18, 2002 · Polyvinyl alcohol (PVA) is the most commonly used emulsifier in the formulation of poly lactide and poly (d, l -lactide-co-glycolide) (PLGA) polymeric nanoparticles. A fraction of …

3 days ago · Then, 200 µL of polyvinyl alcohol (PVA) solution was gradually added to the prepared 3 mL PLGA solution, using an ultrasonic bath for 1 min. This step resulted in the …

Sep 15, 2022 · The results indicated that the system formed by single emulsion containing the combination PVA-PEG presented greater stability with less influence from 5-ALA. This system …