The ability of PKC to phosphorylate GSK3α/β was further confirmed in experiments using the PKC activator phorbol 12-myristate-13-acetate (PMA). PMA robustly stimulated pleckstrin and GSK3α/β phosphorylation in a PKC-dependent, PI3K/Akt-independent, manner (Fig. 2H).

Nov 27, 2021 · Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate each substrate, and why was it evolutionarily favorable for GSK3 to assume such a large responsibility?

Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like …

In this study, we show that GSK3β antagonized TRAIL-induced apoptosis in H1299 NSCLC cells, and determined that the PKCα isozyme is an upstream regulator of GSK3β that phosphorylates and inactivates GSK3β, thereby sensitizing cancer cells to TRAIL-induced apoptosis.

Feb 8, 2013 · Glycogen synthase kinase-3 is a Ser/Thr kinase, tonically active in resting cells but inhibited by phosphorylation of an N-terminal Ser residue (Ser (21) in GSK3α and Ser (9) in GSK3β) in response to varied external stimuli.

In the present study, we examined GSK-3 expression and regulation in human neutrophils. GSK-3α was found to be the predominant isoform, it was constitutively expressed and cell stimulation with different agonists did not alter its expression.

Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. [5] [6] In mice, the enzyme is encoded by the Gsk3b gene. [7] Abnormal regulation and expression of GSK-3 beta is associated with an …

Jan 29, 2003 · Cdc42-dependent phosphorylation of GSK-3β occurs specifically at the leading edge of migrating cells, and induces the interaction of adenomatous polyposis coli (Apc) protein with the plus...

Glycogen Synthase Kinase-3 Beta (GSK-3β) is a serine/threonine protein kinase involved in multiple cellular signaling pathways, including the ERK pathway, and plays a role in promoting apoptosis. It is inhibited by lithium, which affects processes related to …

The ability of PKC to phosphorylate GSK3α/β was further confirmed in experiments using the PKC activator phorbol 12-myristate-13-acetate (PMA). PMA robustly stimulated pleckstrin and GSK3α/β phosphorylation in a PKC-dependent, PI3K/Akt-independent, manner (Fig. 2H).