In this review, we survey the impact of phosphorylation of various ion channels by PKC isoforms and examine the dependence of phosphorylated ion channels on phosphatidylinositol (4,5) bisphosphate as a mechanistic endpoint to control channel gating.

In this review, we survey the impact of phosphorylation of various ion channels by PKC isoforms and examine the dependence of phosphorylated ion channels on phosphatidylinositol (4,5) bisphosphate as a mechanistic endpoint to control channel gating.

Feb 26, 2025 · In this study, we show that calmodulin and protein kinase C-epsilon unmask PIP2 through the dissociation of myristoylated alanine-rich C-kinase substrate from membranes and, thus, rescue basal fusion and potentiate synaptotagmin-1-mediated Ca 2+ …

In this review, we survey the impact of phosphorylation of various ion channels by PKC isoforms and examine the dependence of phosphorylated ion channels on phosphatidylinositol (4,5) bisphosphate as a mechanistic endpoint to control channel gating. The ability of kinases to modulate ion channels is a preva-lent theme in the literature.

Feb 26, 2025 · In this study, we show that calmodulin and protein kinase C–epsilon unmask PIP2 through the dissociation of myristoylated alanine-rich C-kinase substrate from membranes and, thus, rescue basal fusion and potentiate synaptotagmin-1–mediated Ca 2+ …

Our results indicate that the depletion of membrane PIP 2 underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC of the KCNE1 subunit underlies the GqPCR-mediated channel activation.

Sep 9, 2020 · Activation of TRPC1‐based SOCs requires protein kinase C (PKC) activity, which is proposed to phosphorylate TRPC1 proteins to promote channel opening by phosphatidylinositol 4,5‐bisphosphate (PIP 2). We investigated the identity of the PKC isoform involved in activating TRPC1‐based SOCs in rat mesenteric artery VSMCs.

Feb 26, 2025 · Here, we show that Ca 2+/calmodulin (CaM) and protein kinase C (PKC)–epsilon rescue vesicle fusion from the arrest by dissociating the effector domain (ED) of MARCKS from membranes and thus un-masking PIP2. Synaptotagmin-1 is the primary Ca 2+ sensor for fast exocytosis by inducing local membrane bending that lowers energy barrier for fusion ...

May 1, 2022 · In this review, we survey the impact of phosphorylation of various ion channels by PKC isoforms and examine the dependence of phosphorylated ion channels on PIP2 as a mechanistic endpoint to...

Jun 1, 2022 · Canonical activation of cPKCs through the hydrolysis of phosphatidylinositol (4,5) bisphosphate (PI (4,5)P 2 or PIP 2) is shown in Figure 1B. Figure 1. Schematic representation of PKC isozyme structures and conventional PKC (cPKC) activation.